Service offered: Transmission electron microscopy imaging
The electron microscopy Facility at the Leiden University Medical Center (LUMC), offers transmission electron microscopy (TEM) imaging for the analysis of viruses, bacteria, cells, organoids and tissues.
Transmission Electron Microscopy (TEM) provides high resolution imaging for the analysis of all kinds of biological materials, enabling deep insights into the structural details at the nanoscale. TEM supports a wide range of biological samples, ranging from the smallest virus particles, bacteria, cells, to parts of organoids and tissues. The morphology of particles and the inner organization of cells and tissues can be visualized and offers insight. The LUMC has developed automated large scale imaging and visualization tools in combination with supervised machine learning (sML) assisted segmentation of structural features, allowing detection and visualization of structures as well as quantification of structural differences between samples. Imaging is typically performed on plastic embedded and stained sections but can also be performed in 3D using tomography imaging, serial sectioning of serial (SEM) imaging.
Key benefits
- Structural analysis
- Cellular morphology
Applications
- Research
- Sample analysis
Development stage
- Validated
- Available for access
